Alternatives to animal (vertebrate) testing

Alternatives to animal (vertebrate) testing

A large range of data is required when registering a substance under global chemical regulations (such as REACH). This data is gathered through testing, which often means animal testing. However, the use of existing information and alternatives to animal testing should be employed where possible.

A commonly used alternative method is the read-across approach, whereby existing information from analogue substances can be used to predict the properties of the target substance. Other alternative approaches include QSAR modelling (predicting properties and endpoints based on structure), in-vitro methods (tests using isolated cells, organs or tissues), data waiving techniques (justification to omit studies) and weight of evidence approach(combining information from different independent sources).

Our in-depth knowledge of chemical regulation enables us to identify data gaps in a client's chemical information, suggest appropriate alternative methods to animal testing and provide robust justification for their use in the regulatory context. 

If you have any questions regarding QSARs, please contact us to find out more.